Sherpa) demonstrate remarkable hypoxic tolerance, possibly secondary to higher levels of circulating nitric oxide (NO) and increased microcirculatory blood flow. As part of the Xtreme Alps study (a randomised placebo controlled trial of dietary nitrate supplementation under field conditions of hypobaric hypoxia), we investigated whether dietary supplementation with nitrate could improve NO availability and microvascular blood flow in lowlanders. Plasma measurements of nitrate, nitrite and nitroso species were performed together with measurements of sublingual (sidestream dark field camera) and forearm blood flow (venous occlusion plethysmography) in 28 healthy adult volunteers resident at 4559m for 1 week; half receiving a beetroot based high nitrate supplement and half receiving an identically tasting low nitrate ‘placebo’.
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